Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses
نویسندگان
چکیده
Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.
منابع مشابه
A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy
Several randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on sele...
متن کاملA meta-analysis of factors influencing the development of university faculty members
The aim of the present study was to describe, analyze and combine the presented analysis about factors influencing the development of university faculty members through meta-analysis of previously conducted research. The related written works such as thesis and articles registered in Irandoc, Magrian, SID and Nourmags published during 2008-2017 were reviewed. Of these, fifteen studies were sele...
متن کاملThe Analysis of Factors Influencing the Reduction of Abnormal Behaviors in the Workplace Based on Meta-Synthesis Technique
Background and Aim: In recent decades, increasing productivity and reducing losses by improving abnormal behaviors in the workplace have attracted the attention of organizational behavior experts, especially health researchers. The purpose of the present research is to study the factors influencing the reduction of abnormal behaviors in health workplace. Materials and Methods: By using meta-sy...
متن کاملCalcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis
Background: Polycystic ovary syndrome (PCOS) is the most popular endocrine disorder in reproductive age with unknown etiology and many comorbidities. This systematic review focused on the effectiveness of calcium and vitamin D (Ca/ Vit.D) supplementation on metabolic factors, menstrual cycles, and follicular responses in PCOS patients. Methods: Relevant studies were identified from the followi...
متن کاملDetermining Cardiometabolic and Antioxidant Effects of Olive Leaf Extract in Patients with Essential Hypertension
Background Hypertension is one of the most common clinical disorders affecting millions worldwide. Some studies have indicated the role of oxidative stress in the pathogenesis of hypertension and the importance of antioxidant compounds in their control. Objective The aim of this study was to evaluate the effects of Olive Leaf Extract (OLE), Olea europaea L., on cardiometabolic parameters and b...
متن کامل